截止目前，引用Bioss产品发表的文献共23452篇，总影响因子107756.664分，发表在Nature, Science, Cell以及Immunity等顶级期刊的文献共55篇，合作单位覆盖了清华、北大、复旦、华盛顿大学、麻省理工学院、东京大学以及纽约大学等国际知名研究机构上百所。
我们每月收集引用Bioss产品发表的文献。若您在当月已发表SCI文章，但未被我公司收集，请致电Bioss，我们将赠予现金鼓励，金额标准请参考“发文章 领奖金”活动页面。
近期收录2023年1月引用Bioss产品发表的文献共295篇（图一，绿色柱），文章影响因子(IF) 总和高达2000.977，其中，10分以上文献37篇（图二）。
图一
图二
本文主要分享引用Bioss产品发表文章至Nature Nanotechnology, Immunity, Cancer Cell等期刊的5篇 IF＞15 的文献摘要，让我们一起欣赏吧。
Anti-Aquaporin 4 /PE pAb | FCM
作者单位：美国马萨诸塞州波士顿哈佛大学医学院布里格姆妇女医院安·罗姆尼神经疾病中心
摘要：Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Astrocytes are heterogeneous glial cells that are resident in the central nervous system and participate in the pathogenesis of multiple sclerosis and its model experimental autoimmune encephalomyelitis. However, few unique surface markers are available for the isolation of astrocyte subsets, preventing their analysis and the identification of candidate therapeutic targets; these limitations are further amplified by the rarity of pathogenic astrocytes. Here, to address these challenges, we developed focused interrogation of cells by nucleic acid detection and sequencing (FIND-seq), a high-throughput microfluidic cytometry method that combines encapsulation of cells in droplets, PCR-based detection of target nucleic acids and droplet sorting to enable in-depth transcriptomic analyses of cells of interest at single-cell resolution. We applied FIND-seq to study the regulation of astrocytes characterized by the splicing-driven activation of the transcription factor XBP1, which promotes disease pathology in multiple sclerosis and experimental autoimmune encephalomyelitis. Using FIND-seq in combination with conditional-knockout mice, in vivo CRISPR–Cas9-driven genetic perturbation studies and bulk and single-cell RNA sequencing analyses of samples from mouse experimental autoimmune encephalomyelitis and humans with multiple sclerosis, we identified a new role for the nuclear receptor NR3C2 and its corepressor NCOR2 in limiting XBP1-driven pathogenic astrocyte responses. In summary, we used FIND-seq to identify a therapeutically targetable mechanism that limits XBP1-driven pathogenic astrocyte responses. FIND-seq enables the investigation of previously inaccessible cells, including rare cell subsets defined by unique gene expression signatures or other nucleic acid markers.
ADVANCED MATERIALS
[IF=32.086]
作者单位：CAS化学研究院分子科学研究所绿色印刷卓越研究教育中心重点实验室
摘要：Fast and accurate detection of microbial cells in clinical samples is highly valuable but remains a challenge. Here, a simple, culture-free diagnostic system is developed for direct detection of pathogenic bacteria in water, urine and serum samples using an optical colorimetric biosensor. It consists of printed nanoarrays chemically conjugated with specific antibodies that exhibits distinct color changes after capturing target pathogens. By utilizing the internal capillarity inside an evaporating droplet, target preconcentration is achieved within a few minutes to enable rapid identification and more efficient detection of bacterial pathogens. More importantly, the scattering signals of bacteria can be significantly amplified by the nanoarrays due to strong near-field localization, which supports a visualizable analysis of the growth, reproduction and cell activity of bacteria at the single-cell level. Finally, in addition to high selectivity, this nanoarray-based biosensor is also capable of accurate quantification and continuous monitoring of bacterial load on food over a broad linear range, with a detection limit of 10 CFU mL−1. This work provides an accessible and user-friendly tool for point-of-care testing of pathogens in many clinical and environmental applications, and possibly enables a breakthrough in early prevention and treatment.
NATURE IMMUNOLOGY
[IF=31.25]
文献引用抗体：bs-6480R
作者单位：美国马萨诸塞州伍斯特市马萨诸塞大学陈医学院病理科
摘要：Immunoglobulin A (IgA) secretion by plasma cells, terminally differentiated B cells residing in the intestinal lamina propria, assures microbiome homeostasis and protects the host against enteric infections. Exposure to diet-derived and commensal-derived signals provides immune cells with organizing cues that instruct their effector function and dynamically shape intestinal immune responses at the mucosal barrier. Recent data have described metabolic and microbial inputs controlling T cell and innate lymphoid cell activation in the gut; however, whether IgA-secreting lamina propria plasma cells are tuned by local stimuli is completely unknown. Although antibody secretion is considered to be imprinted during B cell differentiation and therefore largely unaffected by environmental changes, a rapid modulation of IgA levels in response to intestinal fluctuations might be beneficial to the host. In the present study, we showed that dietary cholesterol absorption and commensal recognition by duodenal intestinal epithelial cells lead to the production of oxysterols, evolutionarily conserved lipids with immunomodulatory functions. Using conditional cholesterol 25-hydroxylase deleter mouse line we demonstrated that 7α,25-dihydroxycholesterol from epithelial cells is critical to restrain IgA secretion against commensal- and pathogen-derived antigens in the gut. Intestinal plasma cells sense oxysterols via the chemoattractant receptor GPR183 and couple their tissue positioning with IgA secretion. Our findings revealed a new mechanism linking dietary cholesterol and humoral immune responses centered around plasma cell localization for efficient mucosal protection.
NATURE CELL BIOLOGY
[IF=28.213]
作者单位：中国广州中山大学中山医学院中山纪念医院RNA生物医学研究所
摘要：
地 址： 北京市通州区马驹桥镇联东U谷西区四期67号楼
联系人： 秦
电 话： 4009019800
传 真： 010-58129612
Email：sales@bioss.com.cn
展会邀请 | 博奥森邀您共赴2024慕尼黑上海分析生化展！
(2024-11-12T00:00 浏览数:4470)
高效抗体推荐 | 精准检测细胞凋亡
(2024-11-12T00:00 浏览数:3837)
Bioss试剂周周荐 | 细胞培养基选择指南，火速收藏
(2024-11-04T00:00 浏览数:6592)
【9月文献战报】Bioss抗体新增高分文献精彩呈现
(2024-11-04T00:00 浏览数:6158)
博奥森促销 | 抗体狂欢、“京”喜不止、直至年终！
(2024-11-04T00:00 浏览数:6593)
科学之旅 | 第122期 细胞凋亡精品重组兔单抗 免费试用
(2024-10-29T00:00 浏览数:6457)
Bioss试剂周周荐 | 超氧化物歧化酶检测试剂盒！
(2024-10-29T00:00 浏览数:7632)
展会回顾 | CSI 2024圆满落幕，博奥森生物闪耀杭州！
(2024-10-29T00:00 浏览数:7245)
Bioss周周荐 | BCA 蛋白定量试剂盒
(2024-10-22T00:00 浏览数:5599)
Bioss 招聘 | 虚位以待 职等你来
(2024-10-22T00:00 浏览数:6306)
