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DNA的化学修饰,可折叠和复杂的构象导致基因打开或关闭 最好的研究表观遗传学机制是CpG DNA甲基化(DNA methylation)和组蛋白修饰(histone modifications) | ||
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癌症Cancer 心血管疾病Cardiovascular Disease 糖尿病/胰岛素抗性Diabetes/Insulin Resistance 神经系统疾病如阿尔茨海默氏症、精神分裂症Neurological Disorders such as Alzheimer’s, Schizophrenia 自身免疫性疾病,如系统性红斑狼疮和类风湿性关节炎Autoimmune Disorders such as Systemic Lupus Erythematosus and Rheumatoid Arthritis | ||
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(1)抗体 (2)多肽 | |
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Bromodomain:~ 110 氨基酸
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阅读原文:http://www.liankebio.com/ProductCenterShow/articleID/2015010027.html