FITC标记的17号染色体开放阅读框57抗体
产品名称： FITC标记的17号染色体开放阅读框57抗体
英文名称： Anti-C17orf57/FITC
产品编号： HZ-9642R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C17orf57/FITC Conjugated antibody
FITC标记的17号染色体开放阅读框57抗体
| 产品编号 | bs-9642R-FITC |
| 英文名称 | Anti-C17orf57/FITC |
| 中文名称 | FITC标记的17号染色体开放阅读框57抗体 |
| 别 名 | Chromosome 17 open reading frame 57; FLJ40342; Hypothetical protein LOC124989; EFC13_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 110kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C17orf57 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: C17orf57 is a 973 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. Similarity: Contains 6 EF-hand domains. Database links: Entrez Gene: 124989 Human SwissProt: Q8IY85 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
C17OF57是由人类染色体17编码的基因编码的973氨基酸蛋白质。第17号染色体占人类基因组的2.5%以上，约有8100万个碱基编码超过1200个基因。两个关键的肿瘤抑制基因与17号染色体相关，即p53和BRCA1。肿瘤抑制基因p53是通过维持细胞命运通过DNA修复与细胞死亡来维持细胞遗传完整性所必需的。p53表达的异常或丢失与恶性细胞生长和Li Fraumeni综合征有关。与p53一样，BRCA1直接参与DNA修复，特别是它被认为是早发性乳腺癌和卵巢癌、结肠腺癌、前列腺癌和输卵管癌易感性的遗传决定因素。17号染色体也与神经纤维瘤病有关，其特征是神经和表皮损伤，Schwann细胞生长失调。亚力山大病、Bito-Hog Dube综合征和Cavava病也与17号染色体有关。