MDM2 polyclonal antibody
产品名称： MDM2 polyclonal antibody
英文名称： MDM2 polyclonal antibody
产品编号： PAB18187
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MDM2.
- Immunogen:
- A synthetic peptide corresponding to human MDM2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- This antibody is specific to MDM2.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Tumor promotion by Mdm2 splice variants unable to bind p53.
Fridman JS, Hernando E, Hemann MT, de Stanchina E, Cordon-Cardo C, Lowe SW.Cancer Res. 2003 Sep 15;63(18):5703-6.
- 2.
- The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress.
Mendrysa SM, Perry ME.Mol Cell Biol. 2000 Mar;20(6):2023-30.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from COS-7 cells, using MDM2 polyclonal antibody (Cat # PAB18187).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 4193
- Protein Accession#:
- Q00987
- Gene Name:
- MDM2
- Gene Alias:
- HDMX,MGC71221,hdm2
- Gene Description:
- Mdm2 p53 binding protein homolog (mouse)
- Omim ID:
- 164785
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq
- Other Designations:
- Mdm2, transformed 3T3 cell double minute 2, p53 binding protein,double minute 2, human homolog of; p53-binding protein,mouse double minute 2 homolog,p53-binding protein MDM2,ubiquitin-protein ligase E3 Mdm2
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