PTPRT monoclonal antibody, clone T20-AF3C7
产品名称： PTPRT monoclonal antibody, clone T20-AF3C7
英文名称： PTPRT monoclonal antibody, clone T20-AF3C7
产品编号： MAB2740
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant PTPRT.
- Immunogen:
- Recombinant protein corresponding to human PTPRT.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:5000)
Immunoprecipitation (2 ug)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion.
Yu J, Becka S, Zhang P, Zhang X, Brady-Kalnay SM, Wang Z.Mol Cancer Res. 2008 Jul;6(7):1106-13.
- 2.
- Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, Polakiewicz RD, Kinzler KW, Vogelstein B, Velculescu VE, Wang ZJ.Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4060-4. Epub 2007 Feb 21.
- 3.
- Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).
Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A.Brain Res. 2006 Oct 20;1116(1):50-7. Epub 2006 Sep 14.
- Applications
- Western Blot (Transfected lysate)
- Immunoblot analysis of cell lysates.
Lane 1 : Bosc23 cell lysate.
Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau (1-441 a. a.).
Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPRT rho (887-1169 a. a.).
Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1.
- Entrez GeneID:
- 11122
- Gene Name:
- PTPRT
- Gene Alias:
- KIAA0283,RPTPrho
- Gene Description:
- protein tyrosine phosphatase, receptor type, T
- Omim ID:
- 608712
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
- Other Designations:
- OTTHUMP00000031658,receptor protein tyrosine phosphatase