FITC标记的KIAA1462蛋白抗体
产品名称： FITC标记的KIAA1462蛋白抗体
英文名称： Anti-KIAA1462/FITC
产品编号： HZ-13762R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KIAA1462/FITC Conjugated antibody
FITC标记的KIAA1462蛋白抗体
| 英文名称 | Anti-KIAA1462/FITC |
| 中文名称 | FITC标记的KIAA1462蛋白抗体 |
| 别 名 | JCAD; Junctional protein associated with coronary artery disease; JCAD_HUMAN; KIAA1462; Uncharacterized protein KIAA1462. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 148kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KIAA1462 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: KIAA1462 is a 1,359 amino acid protein that colocalizes with VE-Cadherin specifically in endothelial cells and not epithelial cells. KIAA1462 is post-translationally phosphorylated at four serine residues and is in involved celluar adhesion. The gene encoding KIAA1462 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious. Subcellular Location: Cell junction, adherens junction (By similarity). Note=Colocalizes with VE-Cadherin, in endothelial cells but not in epithelial cells (By similarity). Database links: Entrez Gene: 57608 Human SwissProt: Q9P266 Human Unigene: 533953 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
KIAA1462是一种1359氨基酸的蛋白质，与VE-Cadherin特异地在内皮细胞而非上皮细胞中共克隆。KIAA1462在四丝氨酸残基上翻译后磷酸化，参与细胞粘附。编码KIAA1462的基因定位于人类10号染色体，包含800多个基因和1.35亿个核苷酸，约占人类基因组的4.5%。PTEN是位于第10染色体上的一个重要的肿瘤抑制基因，当有缺陷时，引起癌症发展的遗传易感性称为考登综合征。10号染色体编码基因ERCC6对DNA修复有重要作用，并与以极度光敏和过早衰老为特征的Cockayne综合征有关。四氢生物喋呤缺乏症和涉及颅骨缺损和面部骨融合的多种综合征也与10号染色体有关。与大多数三体一样，10号染色体三体是罕见的，是有害的。