TBK1 polyclonal antibody
产品名称： TBK1 polyclonal antibody
英文名称： TBK1 polyclonal antibody
产品编号： PAB12859
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TBK1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus 17 amino acids of human TBK1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- A 84 KDa band should be detected. It is human, mouse and rat reactive and has no cross response to IKKa, IKKb, IKKy, or IKKe.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.
Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itie A, Wakeham A, Shahinian A, Henzel WJ, Elia AJ, Shillinglaw W, Mak TW, Cao Z, Yeh WC.EMBO J. 2000 Sep 15;19(18):4976-85.
- 2.
- NAK is an IkappaB kinase-activating kinase.
Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M.Nature. 2000 Apr 13;404(6779):778-82.
- 3.
- NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
Pomerantz JL, Baltimore D.EMBO J. 1999 Dec 1;18(23):6694-704.
- Entrez GeneID:
- 29110
- Protein Accession#:
- NP_037386
- Gene Name:
- TBK1
- Gene Alias:
- FLJ11330,NAK,T2K
- Gene Description:
- TANK-binding kinase 1
- Omim ID:
- 604834
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq
- Other Designations:
- NF-kB-activating kinase
- Gene Pathway
- Related Disease