产品发布日期：PeproTech 2012年9月


Recombinant Human LIF

Catalog Number:
AF-300-05
Synonyms:
Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor (MLPLI)
Description:
LIF是一种多效性细胞因子，由多种类型的细胞，包括T细胞，骨髓单核细胞系，成纤维细胞，肝细胞，心脏和黑色素瘤等产生。LIF通过抑制自发分化来促进胚胎干细胞(ES细胞)的长期维持。LIF的其它活性包括刺激肝脏急性期蛋白的合成，促进胆碱能神经的分化，以及通过抑制脂肪细胞中脂蛋白脂酶的活性而抑制脂肪生成。人与小鼠的LIF间具有种属交叉反应活性。重组人LIF是一个分子量为19.6 kDa的蛋白质，含有180个氨基酸残基，其中包括3个二硫键。生产过程中的所有试剂均为非动物源性。
AA Sequence:
SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
 
 
 
 
Research Interests:


    

        

            

            
Diabetes / Weight Regulation
            

            
Immune System
        
        

            

            
Lipid Metabolism
            

            
Proliferation
        
        

            

            
Stem Cells & Differentiation
            
 
        
    


 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.