FITC标记的活性依赖的神经保护肽抗体
产品名称： FITC标记的活性依赖的神经保护肽抗体
英文名称： Anti-ADNP/FITC
产品编号： HZ-0039R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ADNP/FITC Conjugated antibody
FITC标记的活性依赖的神经保护肽抗体
| 英文名称 | Anti-ADNP/FITC |
| 中文名称 | FITC标记的活性依赖的神经保护肽抗体 |
| 别 名 | Activity dependent neuroprotective protein; Activity dependent neuroprotector; ADNP; NAP; KIAA0784 |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 114kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADNP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The activity dependent neuroprotective protein (ADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Subcellular Location: Nucleus (Potential). Tissue Specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues. Similarity: Contains 9 C2H2-type zinc fingers. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 23394 Human Omim: 611386 Human SwissProt: Q9H2P0 Human Unigene: 570355 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 是一个潜在的转录调节因子，参与正常细胞与肿瘤细胞的增殖调控。 广泛分布于大脑、小脑等组织，在肺、肾、小肠以及睾丸等组织也有微弱的表达。对体外培养的glia缺失神经元细胞有保护作用. |
活动依赖性神经保护蛋白（ADNP）基因在许多肿瘤中频繁扩增，包括乳腺癌、膀胱癌、卵巢癌、胰腺癌和结肠癌。ADNP mRNA在不同的正常组织中大量表达，在恶性细胞中高表达。ADNP与维持细胞存活有关，可能是通过调节p53。编码的蛋白质含有一个同源盒和九个锌指结构域，表明它是一个转录因子。