TLR2 polyclonal antibody
产品名称： TLR2 polyclonal antibody
英文名称： TLR2 polyclonal antibody
产品编号： PAB11280
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TLR2.
- Immunogen:
- A synthetic peptide corresponding to N-terminus of human TLR2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:5000-1:20000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB.
Asehnoune K, Strassheim D, Mitra S, Yeol Kim J, Abraham E.Cell Signal. 2005 Mar;17(3):385-94.
- 2.
- The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction.
McGettrick AF, O'Neill LA.Mol Immunol. 2004 Jul;41(6-7):577-82.
- 3.
- The role of Toll-like receptor 2 in microbial disease and immunity.
Wetzler LM.Vaccine. 2003 Jun 1;21 Suppl 2:S55-60.
- Applications
- Western Blot (Cell lysate)
- Western blot using TLR2 polyclonal antibody (Cat # PAB11280) shows detection of TLR2 in A-20 whole cell lysate in the presence (A) and absence (B) of blocking peptide.
The membrane was probed with the primary antibody diluted to 1 : 1000.
- Entrez GeneID:
- 7097
- Protein Accession#:
- NP_003255;O60603
- Gene Name:
- TLR2
- Gene Alias:
- CD282,TIL4
- Gene Description:
- toll-like receptor 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq
- Other Designations:
- toll/interleukin 1 receptor-like 4
- Gene Pathway
- Related Disease
- Acute Disease
- Aggressive Periodontitis
- Agricultural Workers' Diseases
- Amyloidosis
- Arthritis, Reactive
- Arthritis, Rheumatoid
- Aspergillosis
- Aspergillosis, Allergic Bronchopulmonary
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Bacteremia
- Bacterial Infections
- Bacteriuria
- Behcet Syndrome
- Birth Weight
- Breast Neoplasms
- Bronchial Hyperreactivity