FAS polyclonal antibody
产品名称： FAS polyclonal antibody
英文名称： FAS polyclonal antibody
产品编号： PAB16642
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of FAS.
- Immunogen:
- A synthetic peptide corresponding to amino acids at internal region of human FAS.
- Sequence:
- KTCRKHRKENQGSH
- Host:
- Goat
- Theoretical MW (kDa):
- 37.7, 35.4, 24.8, 16
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize reported isoforms 1 (NP_000034.1), 2 (NP_690610.1) and 3 (NP_690611.1).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Reduced FAS transcription in clones of U937 cells that have acquired resistance to Fas-induced apoptosis.
Blomberg J, Ruuth K, Jacobsson M, Hoglund A, Nilsson JA, Lundgren E.FEBS J. 2009 Jan;276(2):497-508. Epub 2008 Dec 4.
- Entrez GeneID:
- 355
- Protein Accession#:
- NP_000034.1;NP_690610.1;NP_690611.1
- Gene Name:
- FAS
- Gene Alias:
- ALPS1A,APO-1,APT1,CD95,FAS1,FASTM,TNFRSF6
- Gene Description:
- Fas (TNF receptor superfamily, member 6)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq
- Other Designations:
- APO-1 cell surface antigen,CD95 antigen,Fas AMA,Fas antigen,OTTHUMP00000020045,OTTHUMP00000020046,OTTHUMP00000020051,OTTHUMP00000059646,apoptosis antigen 1,tumor necrosis factor receptor superfamily member 6,tumor necrosis factor receptor superfamily, mem
- Interactome
- Related Disease
- Acquired Immunodeficiency Syndrome
- Acute Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Asthma
- Atherosclerosis
- Atrophy
- Autoimmune Diseases
- Autoimmune Lymphoproliferative Syndrome
- Azoospermia
- Bone Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma in Situ
- Carcinoma, Basal Cell
- Carcinoma, Ductal