FITC标记的GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体
产品名称： FITC标记的GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体
英文名称： Anti-GABPB2/FITC
产品编号： HZ-13262R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GABPB2/FITC Conjugated antibody
FITC标记的GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体
| 英文名称 | Anti-GABPB2/FITC |
| 中文名称 | FITC标记的GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体 |
| 别 名 | MGC29891; BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GA binding protein transcription factor beta subunit 1 transcript variant gamma 2; GA binding protein transcription factor, beta subunit 1; GA binding protein transcription factor, beta subunit 2; GA-binding protein subunit beta-1; GABP subunit beta-1; GABP subunit beta-2; GABP1_HUMAN; GABPB; GABPB-1; GABPB-2; GABPB1; GABPB2; NRF2B1; NRF2B2; Nuclear respiratory factor 2; Transcription factor E4TF1-47; Transcription factor E4TF1-53. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GABPB2/GABPB1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-alpha and a GABP-alpha-associated subunit, GABP beta. GABP alpha binds to a specific DNA sequence and GABP beta exists as b1 and b2 splice variants that differ in their C-termini. In primary neuronal cultures, GABP beta is expressed in both the cytoplasm and the nucleus, whereas GABP alpha is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABP alpha beta heterodimer or a GABP alpha b heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo . The GABP alpha beta tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription. Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Subunit: Heterotetramer of two alpha and two beta subunits. Interacts with HCFC1, causing repression of transcriptional activity. Subcellular Location: Nucleus. Similarity: Contains 5 ANK repeats. Database links: Entrez Gene: 2553 Human Entrez Gene: 14391 Mouse Entrez Gene: 364738 Rat Omim: 600610 Human SwissProt: Q06547 Human SwissProt: Q00420 Mouse Unigene: 654350 Human Unigene: 293266 Mouse Unigene: 61149 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转录因子GA结合蛋白（GABP）由Ets相关的GABP-α和GABP-α相关的GABPβ两个亚基组成。GABPα结合到特定的DNA序列，GABPβ存在于B1和B2剪接变异体中，它们的C-末端不同。在原代神经元培养中，GABPβ在细胞质和细胞核中均有表达，而GABPα主要在细胞核中表达。GABP被组成地表达为GABPαβ异源二聚体或GABPαb异源四聚体，它们都可以在体内外修饰GABP依赖的转录。GABPαβ四聚体复合物具有许多不同的功能，如刺激腺病毒E4基因的转录、差异激活人乳腺细胞系BRCA1的表达、增强Tat介导的长末端重复启动子转录激活和病毒等。在某些细胞类型中的复制，充当神经元中细胞色素氧化酶的线粒体和核转录的协调者，并协助rpL32基因转录的调节。