DDX58抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
DDX58抗体

DDX58抗体

商家询价

产品名称： DDX58抗体

英文名称： DDX58Antibody

产品编号： XY25068-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 DDX58抗体

Applications
In-house applications ELISA, WB, IHC, IP     Application not tested? Please see our Guarantee.
Species specificity Human; other species not tested.
Images
Prev12NextView more validation data
  • 25068-1-AP;A431 cellsA431 cells were subjected to SDS PAGE followed by western blot with 25068-1-AP( DDX58 Antibody) at dilution of 1:600
  • 25068-1-AP;A431 cellsIP Result of anti-DDX58 (IP:25068-1-AP, 4ug; Detection:25068-1-AP 1:600) with A431 cells lysate 1200ug.
  • 25068-1-AP;human heart tissueImmunohistochemistry of paraffin-embedded human heart tissue slide using 25068-1-AP( DDX58 Antibody) at dilution of 1:50 (under 10x lens)
  • 25068-1-AP;human heart tissueImmunohistochemistry of paraffin-embedded human heart tissue slide using 25068-1-AP( DDX58 Antibody) at dilution of 1:50 (under 40x lens)
Positive WB detected in A431 cells
Positive IP detected in A431 cells
Positive IHC detected in Human heart tissue, human colon tissue
Recommended dilution WB : 1:200-1:2000
IP : 1:200-1:2000
IHC : 1:20-1:200
 DDX58抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen DDX58 fusion protein ag18585 Full name DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Calculated molecular
weight		 925aa,107 kDa Observed molecular 
weight		 101 kDa
GenBank accession 
number		 BC132786 Gene ID (NCBI) 23586
Gene symbol DDX58 Synonyms DDX58, DEAD box protein 58, DKFZp434J1111, DKFZp686N19181, FLJ13599, RIG 1, RIG I
Background DDX58抗体

DDX58, also named as RIG-1, belongs to the helicase family. It is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). It is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. DDX58抗体

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