ICAM1 monoclonal antibody, clone 15.2
产品名称： ICAM1 monoclonal antibody, clone 15.2
英文名称： ICAM1 monoclonal antibody, clone 15.2
产品编号： MAB4149
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native ICAM1.
- Immunogen:
- Native purified CDRheumatoid synovial cells and human monocytes.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- Recognizes the (85-115 KDa) intercellular adhesion molecule ICAM-1 which permits antigen-independent adhesion between lymphocytes and their targets. The LFA-1 binding site is located in domain 1 of ICAM-1. The CD54 antigen is a membrane glycoprotein with a wide tissue distribution that includes vascular endothelium and many cells of the immune system. CD54 is weakly expressed on resting peripheral blood lymphocytes. Upon activation by mitogens, the CD54 antigen is strongly expressed on B-cells, T-cells, macrophages and granulocytes. CD54 is the receptor for rhinoviruses and malaria.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 10 mM PBS, pH 7.2 (1% BSA, 0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (1ug stain 1.0x106 cells)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.
Dransfield I, Cabanas C, Barrett J, Hogg N.J Cell Biol. 1992 Mar;116(6):1527-35.
- 2.
- The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site.
Berendt AR, McDowall A, Craig AG, Bates PA, Sternberg MJ, Marsh K, Newbold CI, Hogg N.Cell. 1992 Jan 10;68(1):71-81.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 3383
- Gene Name:
- ICAM1
- Gene Alias:
- BB2,CD54,P3.58
- Gene Description:
- intercellular adhesion molecule 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq
- Other Designations:
- cell surface glycoprotein P3.58,human rhinovirus receptor,intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
- Interactome
- Related Disease
- Acute Disease
- Albuminuria
- Alzheimer Disease
- Alzheimer disease
- Amyotrophic Lateral Sclerosis
- Amyotrophic lateral sclerosis
- Anemia
- Anemia, Sickle Cell
- Anemia, sickle cell
- Angina Pectoris
- Arterial Occlusive Diseases
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Astrocytoma
- Atherosclerosis
- Atherosclerosis
- Autoimmune Diseases
- Behcet Syndrome