FITC标记的细胞色素P450 2D6抗体
产品名称： FITC标记的细胞色素P450 2D6抗体
英文名称： Anti-CYP2D6/FITC
产品编号： HZ-2991R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CYP2D6/FITC Conjugated antibody
FITC标记的细胞色素P450 2D6抗体
| 英文名称 | Anti-CYP2D6/FITC |
| 中文名称 | FITC标记的细胞色素P450 2D6抗体 |
| 别 名 | Cytochrome P450 2D6; CPD6; CYP2D; CYP2D6; CYP2DL1; CYPIID6; Cytochrome P450 family 2 subfamily D polypeptide 6; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; MGC120389; MGC120390; Microsomal monooxygenase; P450 DB1; P450C2D; P450DB1; Xenobiotic monooxygenase; CP2D6_HUMAN; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Cat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CYP2D6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. Function: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Subcellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Similarity: Belongs to the cytochrome P450 family. Database links: Entrez Gene: 1565 Human Omim: 124030 Human SwissProt: P10635 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码细胞色素P450酶家族的一个成员。细胞色素P450蛋白是单加氧酶，催化许多药物代谢和胆固醇、类固醇和其他脂类的合成反应。这种蛋白质定位于内质网，已知代谢多达25%种常用处方药物。它的底物包括抗抑郁药、抗精神病药、止痛药和止*药、β-肾上腺素能阻断剂、抗心律失常药和止吐药。该基因在人类群体中具有高度多态性；某些等位基因导致贫metabolizer phenotype，其特征在于酶底物的代谢能力降低。一些可怜的metabolizer phenotype的个体没有功能蛋白，因为它们携带2个空等位基因，而在其他个体中没有基因。该基因可以在拷贝数上有所变化，并且具有超新陈代谢表型的个体可以具有3个或更多的活性拷贝。另一种编码不同的异构体的剪接转录变体已被发现用于该基因。[ RefSeq，JUL 2014 ]提供。