中文名称 神经生长因子β重组兔单克隆抗体 
别    名 Beta nerve growth factor; NGF-beta; Beta nerve growth factor precursor; Beta NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor beta; Nerve growth factor beta polypeptide; Nerve growth factor beta subunit; NGF B; NID67; NGF beta; NGF-B; NGF_HUMAN.   
研究领域 发育生物学  神经生物学  细胞因子   
抗体来源 Rabbit 
克隆类型 Monoclonal 
克 隆 号 11G1 
交叉反应 Mouse, Rat,  (predicted: Human, Zebrafish, ) 
产品应用 WB=1:1000-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. 
分 子 量 13/32kDa 
细胞定位 分泌型蛋白  
性    状 Liquid 
浓    度 1mg/ml 
免 疫 原 Recombinant human NGF:  
亚    型 IgG 
纯化方法 affinity purified by Protein A 
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 
PubMed PubMed 
产品介绍 This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

DISEASE:
Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and 
产品图片

Sample:
Lane 1: Cerebrum (Mouse) Lysate at 40 ug
Lane 2: Cerebrum (Rat) Lysate at 40 ug
Lane 3: Heart (Mouse) Lysate at 40 ug
Lane 4: Heart (Rat) Lysate at 40 ug
Lane 5:Spleen (Rat) Lysate at 40 ug
Lane 6: Placenta (Mouse) Lysate at 40 ug
Primary: Anti-NGF (bsm-52362R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 32 kD
Observed band size: 34 kD