FITC标记的G蛋白偶联受体45抗体
产品名称： FITC标记的G蛋白偶联受体45抗体
英文名称： Anti-GPR45/FITC
产品编号： HZ-13538R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPR45/FITC Conjugated antibody
FITC标记的G蛋白偶联受体45抗体
| 英文名称 | Anti-GPR45/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体45抗体 |
| 别 名 | GPCR GPR45; G protein coupled receptor 45; High affinity lysophosphatidic acid receptor; Probable G protein coupled receptor 45; GPCR 45; PSP24 1; PSP24 alpha; PSP24; PSP24(ALPHA); PSP241; PSP24A. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR45 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR45, also known as PSP24-1 or PSP24-α, is a 372 amino acid orphan receptor that is suspected to play a role in brain function. Expressed in brain, GPR45 has been detected in the basal forebrain, frontal cortex and caudate, but not in thalamus, hippocampus or putamen. Function: GPCR GPR54 is a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. GPR45 is an orphan receptor, which may play a role in brain function. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 11250 Human Omim: 604838 Human SwissProt: Q9Y5Y3 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体(GPR)是跨膜受体的蛋白家族，将细胞外信号(配体结合)传递到细胞内信号(G蛋白激活)。GPR信号是所有真核生物用来感知环境刺激并介导细胞-细胞通讯的进化古老机制。所有的受体都有七个跨膜结构域，受体的胞外部分可以糖基化。这些细胞外环还含有两个高度保守的半胱氨酸残基，它们产生二硫键以稳定受体结构。GPR45，也称为PSP24-1或PSP24-α，是一种372氨基酸的孤儿受体，被怀疑在脑功能中发挥作用。GPR45在大脑中表达于基底前脑、额叶皮质和尾状核，而在丘脑、海马和壳核中未见表达。