FITC标记的反义导向分子RGMB抗体
产品名称： FITC标记的反义导向分子RGMB抗体
英文名称： Anti-Repulsive Guidance Molecule B/FITC
产品编号： HZ-11474R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Repulsive Guidance Molecule B/FITC Conjugated antibody
FITC标记的反义导向分子RGMB抗体
| 产品编号 | bs-11474R-FITC |
| 英文名称 | Anti-Repulsive Guidance Molecule B/FITC |
| 中文名称 | FITC标记的反义导向分子RGMB抗体 |
| 别 名 | RGMB; Dragon; DRG11-responsive axonal guidance and outgrowth of neurite; Repulsive Guidance Molecule B; RGM b; RGM domain family member B; Rgmb; RGMB_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 干细胞 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH). Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. Subunit: Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft Post-translational modifications: GPI-anchored. Similarity: Belongs to the repulsive guidance molecule (RGM) family. Database links: Entrez Gene: 285704 Human Entrez Gene: 68799 Mouse Omim: 612687 Human SwissProt: Q6NW40 Human SwissProt: Q7TQ33 Mouse Unigene: 526902 Human Unigene: 293466 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
排斥性指导分子（RGM）家族在发育神经元的生长锥的引导中起着重要作用。他们是排斥的一组轴突，那些从视网膜的一半时间。RGM与轴突导向和神经管闭合都有牵连，但与Errin、SimaPrrin、NeRIN和SRIT相反，没有定义RGM活化的受体机制。背根神经节轴突不响应RGM，但NeGu蛋白（NETRIN结合蛋白，它可以作为RGM受体）的表达可以刺激RGM的反应性。RGM蛋白通过GPI锚钉附着在膜上。这个家族的两个成员，RGMa和RGMB，都在神经系统中表达。RGMc，也称为HydoJulin，是激活HePCIDIN的信号通路的一部分，与HePCIDIN共同作用，以限制肠道中的铁吸收。RGMC基因的缺陷导致常染色体隐性遗传性青少年血色素沉着症（JH）。