LIMK2 polyclonal antibody
产品名称： LIMK2 polyclonal antibody
英文名称： LIMK2 polyclonal antibody
产品编号： PAB3486
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LIMK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LIMK2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Cloning and characterization of the alternative promoter regions of the human LIMK2 gene responsible for alternative transcripts with tissue-specific expression.
Nomoto S, Tatematsu Y, Takahashi T, Osada H.Gene. 1999 Aug 20;236(2):259-71.
- 2.
- Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation.
Osada H, Hasada K, Inazawa J, Uchida K, Ueda R, Takahashi T, Takahashi T.Biochem Biophys Res Commun. 1996 Dec 13;229(2):582-9.
- 3.
- Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.
Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K.J Biol Chem. 1995 Dec 29;270(52):31321-30.
- Entrez GeneID:
- 3985
- Protein Accession#:
- P53667
- Gene Name:
- LIMK2
- Gene Alias:
- -
- Gene Description:
- LIM domain kinase 2
- Omim ID:
- 601988
- Gene Ontology:
- Hyperlink
- Gene Summary:
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- -