CARD8 polyclonal antibody
产品名称： CARD8 polyclonal antibody
英文名称： CARD8 polyclonal antibody
产品编号： PAB12906
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CARD8.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human CARD8.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- An approximate 45 KDa can be detected.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, Alnemri ES.J Biol Chem. 2002 Apr 19;277(16):13952-8. Epub 2002 Jan 30.
- 2.
- TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.
Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC.J Biol Chem. 2001 Aug 24;276(34):32220-9. Epub 2001 Jun 14.
- 3.
- DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis.
Scholl FA, McLoughlin P, Ehler E, de Giovanni C, Schafer BW.J Cell Biol. 2000 Oct 30;151(3):495-506.
- Entrez GeneID:
- 22900
- Protein Accession#:
- AAG50014
- Gene Name:
- CARD8
- Gene Alias:
- CARDINAL,DACAR,DKFZp779L0366,Dakar,FLJ18119,FLJ18121,KIAA0955,MGC57162,NDPP,NDPP1,TUCAN
- Gene Description:
- caspase recruitment domain family, member 8
- Omim ID:
- 609051
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
- Other Designations:
- CARD inhibitor of NF-kappaB-activating ligands,CARD8 isoform T47,CARD8 isoform T51,CARD8 isoform T60,apoptotic protein NDPP1,tumor up-regulated CARD-containing antagonist of caspase nine
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Arthritis
- Arthritis, Rheumatoid
- Bacterial Infections
- Colitis, Ulcerative
- Colorectal Neoplasms
- Crohn Disease
- Crohn's disease
- Disease Progression
- Encephalitis
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Inflammatory Bowel Diseases
- Tobacco Use Disorder