HRAS monoclonal antibody, clone H-RAS-03
产品名称: HRAS monoclonal antibody, clone H-RAS-03
英文名称: HRAS monoclonal antibody, clone H-RAS-03
产品编号: MAB3617
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of HRAS.
- Immunogen:
- A synthetic peptide corresponding to human HRAS.
- Sequence:
- DIHQYREQIKRVKDSDDC
- Host:
- Mouse
- Theoretical MW (kDa):
- 21
- Reactivity:
- Human
- Specificity:
- This antibody reacts with human HRAS, an ubiquitously expressed 21 KDa intracellular protein. Although reactivity with other species has not been determined, it is probable as the epitope is highly conserved among animals.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Hsp90 molecular chaperone: an open and shut case for treatment.
Pearl LH, Prodromou C, Workman P.Biochem J. 2008 Mar 15;410(3):439-53.
- 2.
- Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.
Millson SH, Truman AW, Racz A, Hu B, Panaretou B, Nuttall J, Mollapour M, Soti C, Piper PW.FEBS J. 2007 Sep;274(17):4453-63. Epub 2007 Aug 6.
- 3.
- Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis.
Hooven TA, Yamamoto Y, Jeffery WR.Int J Dev Biol. 2004;48(8-9):731-8.
- Applications
- Western Blot (Cell lysate)
- Western Blotting analysis (reducing conditions) of HRAS in whole cell lysate using HRAS monoclonal antibody, clone H-RAS-03 (Cat # MAB3617).
Lane 1 : HeLa, human cervix carcinoma cell line.
Lane 2 : K-567, human leukemia cell line.
Lane 3 : RAJI, human Burkitt lymphoma cell line.
- Entrez GeneID:
- 3265
- Gene Name:
- HRAS
- Gene Alias:
- C-BAS/HAS,C-H-RAS,C-HA-RAS1,CTLO,H-RASIDX,HAMSV,HRAS1,K-RAS,N-RAS,RASH1
- Gene Description:
- v-Ha-ras Harvey rat sarcoma viral oncogene homolog
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq
- Other Designations:
- GTP- and GDP-binding peptide B,GTPase HRas,Ha-Ras1 proto-oncoprotein,OTTHUMP00000162769,OTTHUMP00000166053,OTTHUMP00000166055,Ras family small GTP binding protein H-Ras,c-has/bas p21 protein,c-ras-Ki-2 activated oncogene,p19 H-RasIDX protein,transformatio
- Gene Pathway
- Acute myeloid leukemia
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Endocytosis
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pathways in cancer
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- T cell receptor signaling pathway
- Thyroid cancer
- Tight junction
- VEGF signaling pathway
- Related Disease
- Adenocarcinoma, Papillary
- Adenoma
- Astrocytoma
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Calcinosis
- Carcinoma
- Carcinoma, Papillary
- Carcinoma, Papillary, Follicular
- Carcinoma, Transitional Cell
- Chromosome Deletion
- Chronic Disease
- Cocarcinogenesis
- Cognition Disorders
- Colon cancer
- Colorectal Neoplasms
- Common Bile Duct Neoplasms
- Developmental Disabilities