Murine & Rat Growth Factors & Cytokines
            
Recombinant Murine IL-10
            

            

             
        
        

            
 
            

            

                

                    

                        

                        
Synonyms :
                        
                        

                        
B-TCGF, CSIF, TGIF
                        
                    
                    

                        

                        
Description :
                        
                        

                        
IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.
                        
                    
                    

                        

                        
Catalog #:
                        
                        

                        
210-10
                        
                    
                    

                        

                        
Source :
                        
                        

                        
E.coli
                        
                    
                    

                        

                        
Purity :
                        
                        

                        
Greater than 98% by SDS-PAGE gel and HPLC analyses.
                        
                    
                    

                        

                        
Endotoxin Level :
                        
                        

                        
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
                        
                    
                    

                        

                        
Biological Activity :
                        
                        

                        
PeproTechs murine IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be < 2 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
                        
                    
                    

                        

                        
Selected References :
                        
                        

                        
Selected List of References Citing This PeproTech Product
                        
                    
                    

                        

                        
AA Sequence :
                        
                        

                        
MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S 
                        
                    
                    

                        

                        
PubMed Link :
                        
                        

                        
IL-10+AND+mouse
                        
                    
                    

                        

                        
Country of Origin :
                        
                        

                        
USA
                        
                    
                    

                        
 
                        

                        
                    
                    

                        

                        
 
                        
                        

                        

                        

                            

                                

                                    
Size A
                                    
2μg
                                    
$80 
                                    
 
                                
                                

                                    
 
                                
                                

                                    
Size B
                                    
10μg
                                    
$195 
                                    
 
                                
                                

                                    
 
                                
                                

                                    
Size C
                                    
1mg
                                    
$5200 
                                    
 
                                
                                

                                    
 
                                
                            
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
Special Sizes: 

                        Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
                        
                    
                    

                        

                        
 
                        
                        

                        
Usage:

                        For Research Use Only. Not for use in diagnostic or therapeutic procedures.