STK4/STK3 polyclonal antibody
产品名称： STK4/STK3 polyclonal antibody
英文名称： STK4/STK3 polyclonal antibody
产品编号： PAB18249
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of STK4/STK3.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding T183 of human STK4/STK3.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- This antibody is specific to STK4/STK3.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Mol Cell Biol. 2005 Oct;25(20):8887-903.
Gomez EB, Espinosa JM, Forsburg SL.Mol Cell Biol. 2005 Oct;25(20):8887-903.
- 2.
- J Biol Chem. 2002 Nov 8;277(45):42987-96. Epub 2002 Sep 9.
Glantschnig H, Rodan GA, Reszka AA.J Biol Chem. 2002 Nov 8;277(45):42987-96. Epub 2002 Sep 9.
- 3.
- Blood. 2002 May 1;99(9):3432-8.
De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA.Blood. 2002 May 1;99(9):3432-8.
- Entrez GeneID:
- 6789
- Protein Accession#:
- Q13188
- Gene Name:
- STK4
- Gene Alias:
- DKFZp686A2068,KRS2,MST1,YSK3
- Gene Description:
- serine/threonine kinase 4
- Omim ID:
- 604965
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq
- Other Designations:
- OTTHUMP00000043418,dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)),kinase responsive to stress 2,mammalian sterile 20-like 1,yeast Ste20-like
- Entrez GeneID:
- 6788
- Protein Accession#:
- Q13188
- Gene Name:
- STK3
- Gene Alias:
- FLJ90748,KRS1,MST2
- Gene Description:
- serine/threonine kinase 3 (STE20 homolog, yeast)
- Omim ID:
- 605030
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996 [PubMed 8816758]; Lee et al., 2001 [PubMed 11278283]).[supplied by OMIM
- Other Designations:
- serine/threonine kinase 3 (Ste20, yeast homolog)