FITC标记的FBXL12蛋白抗体
产品名称： FITC标记的FBXL12蛋白抗体
英文名称： Anti-FbxL12/FITC
产品编号： HZ-8466R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FbxL12/FITC Conjugated antibody
FITC标记的FBXL12蛋白抗体
| 产品编号 | bs-8466R-FITC |
| 英文名称 | Anti-FbxL12/FITC |
| 中文名称 | FITC标记的FBXL12蛋白抗体 |
| 别 名 | F box and leucine rich repeat protein 12; F box protein FBL12; F box/LRR repeat protein 12; FBXL 12; FLJ20188; FXL12_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FbxL12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBL12 (F-box and leucine-rich repeat protein 12), also designated FBXL12, is a 326 amino acid protein that contains one F-box domain, five LRR (leucine-rich) repeats and exists as two alternatively spliced isoforms. FBL12 interacts with both Skp1 and CUL-1, and is encoded by a gene that maps to human chromosome 19p13.2. Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Subunit: Interacts with SKP1 and CUL1 (By similarity). Similarity: Contains 1 F-box domain. Contains 8 LRR (leucine-rich) repeats. Database links: UniProtKB/Swiss-Prot: Q9NXK8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
F-盒蛋白是SCF（SKP1-Cul-1-F盒蛋白）型E3泛素连接酶复合体的重要组成部分，参与了泛素化的底物识别和募集。它们是一个更大的蛋白质家族成员，参与调控多种细胞过程（包括细胞周期、免疫应答、信号级联和发育事件），通过靶向蛋白质，如细胞周期素、细胞周期蛋白依赖性激酶抑制剂。S，ⅠB -β-和β-连环蛋白，用于蛋白酶体降解。FBL12（F盒和富含亮氨酸重复蛋白12），也被指定为FbxL12，是包含一个F盒结构域、五个LRR（亮氨酸富集）重复序列的326个氨基酸蛋白质，并作为两个交替剪接的异构体存在。FBL12与Skp1和Cul-1两者相互作用，并由一个映射到人类染色体19p132的基因编码。