Human Growth Factors & Cytokines
Recombinant Human NNT-1 /BCSF-3





 





		Synonyms :
Novel Neurtrophin-1/B-Cell Stimulating Factor-3, Cardiotrophin-like cytokine



		Description :
NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities.  Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-β) and induces tyrosine phosphorylation of these receptors.  In vitro, it supports the survival of chick embryo motor and sympathetic neurons.  In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM.  Recombinant human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.



		Catalog #:
450-18



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.



                AA Sequence :
MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF 



		PubMed Link :
B-cell+AND+stimulating+AND+factor-3+AND+human


Country of Origin :
USA
















        Size A
2μg
$80 
 


 



        Size B
10μg
$195 
 


 



        Size C
1mg
$5200 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.