FITC标记的细胞角蛋白12抗体
产品名称： FITC标记的细胞角蛋白12抗体
英文名称： Anti-CK12/FITC
产品编号： HZ-4625R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CK12/FITC Conjugated antibody
FITC标记的细胞角蛋白12抗体
| 英文名称 | Anti-CK12/FITC |
| 中文名称 | FITC标记的细胞角蛋白12抗体 |
| 别 名 | 65 kDa cytokeratin; CK 12; CK 3; CK12; CK3; Cytokeratin 12; Cytokeratin 3; K12; K3; keratin 12 (Meesmann corneal dystrophy); Keratin 12; Keratin 3; Keratin, type I cytoskeletal 12; K1C12_HUMAN; Keratin, type II cytoskeletal 3; KRT12; KRT3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞类型标志物 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CK12/Cytokeratin 12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cytokeratin 12 is a member of the intermediate filament family of proteins and is a heterotetramer of two type I and two type II keratins. Keratin 3 is specifically expressed in the corneal epithelium with family member KRT12. Cytokeratin 12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Defects in KRT3 and KRT12 are a cause of Meesmann corneal dystrophy (MCD), an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Symptoms occur in adulthood and include rupture of the corneal microcysts that may lead to photophobia, contact lens intolerance and intermittent diminution of visual acuity. Defects in KRT12 are a cause of juvenile epithelial corneal dystrophy of Meesmann (MCD) Function: May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity). Subunit: Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12. Tissue Specificity: Cornea specific. DISEASE: Corneal dystrophy, Meesmann (MECD) [MIM:122100]: An autosomal dominant corneal disease characterized by fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the intermediate filament family. Database links: Entrez Gene: 3859 Human Entrez Gene: 268482 Mouse Entrez Gene: 360625 Rat Omim: 601687 Human SwissProt: Q99456 Human SwissProt: Q64291 Mouse SwissProt: Q6IFW5 Rat Unigene: 66739 Human Unigene: 436651 Mouse Unigene: 94852 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞角蛋白12是蛋白质中间丝家族的成员，是两种I型和2类II型角蛋白的异源四聚体。角蛋白3在角膜上皮中与KRT12家族成员特异表达。细胞角蛋白12编码I型中间丝链角蛋白12，在角膜上皮中表达。KRT3和KRT12的缺陷是导致Meesmann corneal营养不良（MD）的原因，MD是一种常染色体显性疾病，导致前角膜上皮的脆性。症状发生在成年期，包括破裂的角膜微囊，可能导致畏光，隐形眼镜不耐受和间歇性减少视力。KRT12的缺陷是MeSSMAN（MCD）幼年上皮性角膜营养不良的原因之一