FITC标记的谷胱甘肽S转移酶α1抗体
产品名称： FITC标记的谷胱甘肽S转移酶α1抗体
英文名称： Anti-GSTA1/FITC
产品编号： HZ-13398R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GSTA1/FITC Conjugated antibody
FITC标记的谷胱甘肽S转移酶α1抗体
| 英文名称 | Anti-GSTA1/FITC |
| 中文名称 | FITC标记的谷胱甘肽S转移酶α1抗体 |
| 别 名 | Glutathione S alkyltransferase A1; Glutathione S aralkyltransferase A1; Glutathione S aryltransferase A1; Glutathione S transferase 2; Glutathione S transferase A1; Glutathione S transferase alpha 1; Glutathione S transferase Ha subunit 1; Glutathione S-transferase A1; GST 2; GST class alpha; GST class alpha 1; GST class alpha member 1; GST class-alpha member 1; GST epsilon; GST HA subunit 1; GST, class alpha, 1; GST-epsilon; GST2; GSTA 1; GSTA1 1; GSTA1; GSTA1 protein; GSTA1-1; GSTA1_HUMAN; GTH 1; GTH1; HA subunit 1; MGC131939; OTTHUMP00000016611; S (hydroxyalkyl)glutathione lyase A1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GSTA1/Glutathione S Transferase alpha |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. GSTs are differentially expressed in lung, liver and kidney tissue. Three isoforms, GSTA1-1, GSTA1-4 and GSTM1, localize to the mitochondria in addition to the cytoplasm. In normal and transformed cells, the oncoprotein Myb transcriptionally upregulates GSTM1. This isoform shows high specific activity for aflatoxin B1 epoxide conjugation, suggesting an important role for this interaction in the defense against both chemical and oxidative stress. The C-terminal domain of GSTA1 may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity. Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Subunit: Homodimer or heterodimer of GSTA1 and GSTA2. Subcellular Location: Cytoplasm. Tissue Specificity: Liver. Similarity: Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain. Database links: Entrez Gene: 2938 Human Entrez Gene: 14857 Mouse Entrez Gene: 24421 Rat Omim: 138359 Human SwissProt: P08263 Human SwissProt: P13745 Mouse SwissProt: P00502 Rat Unigene: 446309 Human Unigene: 467426 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
谷胱甘肽S-转移酶（GST）蛋白家族的成员在外源生物的解毒中具有保护细胞免受毒性损伤的作用。GSTs在肺、肝、肾组织中均有不同程度的表达。三种异构体，GSTA1-1，GSTA1-4和GSTM1，定位到线粒体除了细胞质。在正常和转化的细胞中，癌基因MYB转录上调GSTM1。该异构体显示黄曲霉毒素B1环氧化物结合的高比活性，表明这种相互作用在抵抗化学和氧化应激方面具有重要作用。GSTA1的C-末端结构域可以形成疏水性底物结合位点的组分，但是相比之下，它似乎不直接参与GSH结合，并且对于催化活性不是绝对必要的。