磷酸化内收蛋白抗体
产品名称： 磷酸化内收蛋白抗体
英文名称： phospho-alpha Adducin (Thr445)
产品编号： hz-12961R
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
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Rabbit Anti-phospho-alpha Adducin (Thr445) antibody
| 产品编号 | hz-12961R |
| 英文名称 | phospho-alpha Adducin (Thr445) |
| 中文名称 | 磷酸化内收蛋白抗体 |
| 别 名 | Adducin (phospho T445); p-Adducin (phospho T445); ADD1; ADDA; Adducin 1 (alpha); Adducin 1; Alpha adducin; ADDA_HUMAN. |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 80kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Thr445:EK(p-T)RW |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Subunit: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Subcellular Location: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. Similarity: Belongs to the aldolase class II family. Adducin subfamily. Gene ID: 118 Database links:
Entrez Gene: 118 Human Entrez Gene: 11518 Mouse Entrez Gene: 24170 Rat Omim: 102680 Human SwissProt: P35611 Human SwissProt: Q9QYC0 Mouse SwissProt: Q63028 Rat Unigene: 183706 Human Unigene: 289106 Mouse
Unigene: 5788 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |