FITC标记的转运蛋白DISP2抗体
产品名称： FITC标记的转运蛋白DISP2抗体
英文名称： Anti-DISP2/FITC
产品编号： HZ-11588R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DISP2/FITC Conjugated antibody
FITC标记的转运蛋白DISP2抗体
| 产品编号 | bs-11588R-FITC |
| 英文名称 | Anti-DISP2/FITC |
| 中文名称 | FITC标记的转运蛋白DISP2抗体 |
| 别 名 | DISP 2; Dispatched B; Dispatched homolog 2 (Drosophila); Dispatched homolog 2; DISPB; DKFZp547N223; HsT16908; KIAA1742; Protein dispatched homolog 2; DISP2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 转录调节因子 细胞表面分子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 152kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DISP2 (1101-1200aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the dispatched family. Contains 1 SSD (sterol-sensing) domain. Database links: UniProtKB/Swiss-Prot: A7MBM2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DISS2是三个已知的黑腹果蝇蛋白同源物中的第二个。它是一种含有两个PTCH/DISP结构域的多跨膜蛋白，被认为参与了从产生细胞中释放脂质锚定的刺猬。刺猬是胚胎发育、组织再生和癌变过程中信号通路的主要参与者，DISP蛋白参与了这些途径。最近，已经表明，DISP2是由microRNA miR214在斑马鱼中翻译调控的。这种miRNA的表达降低了DISP2启动子活性，其在斑马鱼中的过度表达导致了与DISC2突变体所观察到的表型相同的表型。已知存在至少两种DISP2异构体。