COP1 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
COP1 抗体

COP1 抗体

商家询价

产品名称： COP1 抗体

英文名称： COP1 Antibody

产品编号： XY13542-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 COP1 抗体

Applications
In-house applications ELISA     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
 
Recommended dilution  
 COP1 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen COP1 fusion protein ag4484 Full name Ring finger and WD repeat domain 2
Calculated molecular
weight		 731aa,80 kDa Observed molecular 
weight		 90 kDa
GenBank accession 
number		 BC039723 Gene ID (NCBI) 64326
Gene symbol RFWD2 Synonyms COP1, FLJ10416, hCOP1, RFWD2, RING finger protein 200, RNF200
Background COP1 抗体

COP1 is also named as RFWD2, RNF200 and belongs to the COP1 family. It is a ubiquitin ligase that targets key regulators for degradation, and DET1 complexes with COP10 and DDB1, which is proposed to aid in COP1-mediated degradation (PMID:22705257). The endogenous COP1 is localized predominantly in the nucleus, but small amount may also be present in the cytosol. Within the nucleus, COP1 is present in both the nucleoplasm (NP) and the nuclear envelope (NE) fractions, although COP1 is more enriched in the nucleoplasm (PMID:12466024). Two of the COP1 isoforms identified by RNA-seq analysis predicted the size of two proteins detected by the antibody for COP1, a 75 kDa band, corresponding to the longer isoform, and a 50 kDa band corresponding to the shorter isoform. (PMID:24714719). It has been shown that COP1 forms dimerization through its coiled-coil region. COP1 抗体

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