SMAD4 (phospho T277) polyclonal antibody
产品名称： SMAD4 (phospho T277) polyclonal antibody
英文名称： SMAD4 (phospho T277) polyclonal antibody
产品编号： PAB1965
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SMAD4.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to residues surrounding T277 of human SMAD4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Transforming growth factor-?]1 attenuates junctional adhesion molecule-A and contributes to breast cancer cell invasion.
Wang Y, Lui WY.Eur J Cancer. 2012 May 28.
- 2.
- Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling.
Sekiya T, Oda T, Matsuura K, Akiyama T.Biochem Biophys Res Commun. 2004 Jul 30;320(3):680-4.
- 3.
- Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.
Horvath LG, Henshall SM, Kench JG, Turner JJ, Golovsky D, Brenner PC, O'Neill GF, Kooner R, Stricker PD, Grygiel JJ, Sutherland RL.Prostate. 2004 May 15;59(3):234-42.
- 4.
- CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.
Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, Zhang S, Fu XY, Chang Z.Mol Cell Biol. 2004 Jan;24(2):856-64.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with SMAD4 (phospho T277) polyclonal antibody (Cat # PAB1965) which was peroxidase-conjugated to the secondary antibody followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 4089
- Protein Accession#:
- NP_005350;Q13485
- Gene Name:
- SMAD4
- Gene Alias:
- DPC4,JIP,MADH4
- Gene Description:
- SMAD family member 4
- Gene Ontology:
- Hyperlink
- Other Designations:
- MAD, mothers against decapentaplegic homolog 4,OTTHUMP00000163548,SMAD, mothers against DPP homolog 4,deleted in pancreatic carcinoma locus 4,mothers against decapentaplegic homolog 4,mothers against decapentaplegic, Drosophila, homolog of, 4
- Interactome
- Related Disease
- Adenocarcinoma
- Adenomatous Polyposis Coli
- Carcinoma, Adenosquamous
- Carcinoma, Pancreatic Ductal
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Deletion
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Disease Models, Animal
- Edema
- Gastrointestinal Neoplasms
- Genetic Predisposition to Disease