WASL (phospho Y256) polyclonal antibody
产品名称： WASL (phospho Y256) polyclonal antibody
英文名称： WASL (phospho Y256) polyclonal antibody
产品编号： PAB7899
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of WASL.
- Immunogen:
- Synthetic phosphopeptide (conjugated with BSA) corresponding to residues surrounding Y256 of human WASL.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- The human WASP sequence has a two amino acid difference in the same region surrounding tyrosine 291.
- Form:
- Liquid
- Storage Buffer:
- In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:20000)
Western Blot (1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Focal adhesion kinase regulation of N-WASP subcellular localization and function.
Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL.J Biol Chem. 2004 Mar 5;279(10):9565-76. Epub 2003 Dec 15.
- 2.
- Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Torres E, Rosen MK.Mol Cell. 2003 May;11(5):1215-27.
- 3.
- Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.
Baba Y, Nonoyama S, Matsushita M, Yamadori T, Hashimoto S, Imai K, Arai S, Kunikata T, Kurimoto M, Kurosaki T, Ochs HD, Yata J, Kishimoto T, Tsukada S.Blood. 1999 Mar 15;93(6):2003-12.
- Entrez GeneID:
- 8976
- Gene Name:
- WASL
- Gene Alias:
- DKFZp779G0847,MGC48327,N-WASP,NWASP
- Gene Description:
- Wiskott-Aldrich syndrome-like
- Omim ID:
- 605056
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq
- Other Designations:
- Wiskott-Aldrich syndrome gene-like,Wiskott-Aldrich syndrome gene-like protein,neural Wiskott-Aldrich syndrome protein