FITC标记的环指蛋白调节蛋白激酶C蛋白抗体
产品名称： FITC标记的环指蛋白调节蛋白激酶C蛋白抗体
英文名称： Anti-TRIM41/FITC
产品编号： HZ-9151R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TRIM41/FITC Conjugated antibody
FITC标记的环指蛋白调节蛋白激酶C蛋白抗体
| 产品编号 | bs-9151R-FITC |
| 英文名称 | Anti-TRIM41/FITC |
| 中文名称 | FITC标记的环指蛋白调节蛋白激酶C蛋白抗体 |
| 别 名 | RINCK; RING finger protein that interacts with C kinase; Trim41; Tripartite motif containing 41; TRI41_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 72kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRIM41 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Tripartite motif-containing protein 41 (TRIM41), also known as RINCK, is a 630 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Localized to both the nucleus and cytoplasm, TRIM41 associates with protein kinase C (PKC) through the C1A domain of PKC. Studies have shown that overexpression of TRIM41 reduces the levels of PKC in cells, whereas knockdown of TRIM41 leads to increased levels of PKC. Thus, it is hypothesized that TRIM41 plays a role in regulating PCK levels in cells, specifically through the ubiquitination of PKC. Four isoforms of TRIM41 exist as a result of alternative splicing events. Function: Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. Subunit: Interacts with PRKCA. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed in multiple tissues with the highest levels in heart and skeletal muscle. Post-translational modifications: Auto-ubiquitinated. Similarity: Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger. Database links: Entrez Gene: 90933 Human Entrez Gene: 211007 Mouse Entrez Gene: 303088 Rat Omim: 610530 Human SwissProt: Q8WV44 Human SwissProt: Q5NCC3 Mouse Unigene: 441488 Human Unigene: 794 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
包含蛋白质41（Trim41）的三部分基序，也称为RcCK，是TrIM家族的630个氨基酸成员，也称为环状B-盒盘绕线圈（RBCC）家族。RBCC家族的成员具有N-末端环指，其次是一个或两个锌结合结构域（B-盒结构域），亮氨酸卷曲螺旋区和可变的C-末端结构域。定位于细胞核和细胞质中，TUN41通过PKC的C1A结构域与蛋白激酶C（PKC）相关联。研究表明，TUN41的过度表达降低了细胞中PKC的水平，而敲除TUN41则导致PKC水平的升高。因此，推测TIM41在调节细胞中的PCK水平方面起作用，特别是通过UB。