FITC标记的eIF2Bδ蛋白抗体
产品名称： FITC标记的eIF2Bδ蛋白抗体
英文名称： Anti-eIF2B4/FITC
产品编号： HZ-14538R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-eIF2B4/FITC Conjugated antibody
FITC标记的eIF2Bδ蛋白抗体
| 英文名称 | Anti-eIF2B4/FITC |
| 中文名称 | FITC标记的eIF2Bδ蛋白抗体 |
| 别 名 | EI2BD_HUMAN; EIF 2B; eIF 2B GDP GTP exchange factor subunit delta; eIF-2B GDP-GTP exchange factor subunit delta; Eif2b4; EIF2Bdelta; eukaryotic translation initiation factor 2B subunit 4; Translation initiation factor eIF-2B subunit delta. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human eIF2B4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Subunit: Complex of five different subunits; alpha, beta, gamma, delta and epsilon. DISEASE: Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. Database links: Entrez Gene: 8890 Human Entrez Gene: 13667 Mouse Entrez Gene: 117019 Rat Omim: 606687 Human SwissProt: Q3T058 Cow SwissProt: Q9UI10 Human SwissProt: Q61749 Mouse SwissProt: P41111 Rabbit SwissProt: Q63186 Rat Unigene: 169474 Human Unigene: 29394 Mouse Unigene: 11060 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
真核起始因子2B（EIF2B）是由五个不同亚基组成的GTP交换因子，是蛋白质合成所必需的。由该基因编码的蛋白质是第四个或δ亚基。该基因的缺陷是白质脑病的原因，即白质消失（VWM）和卵巢白质营养不良。该基因已发现编码不同亚型的多个转录变体。[ RefSeq，JUL 2008 ]