FITC标记的PARD6G蛋白抗体
产品名称： FITC标记的PARD6G蛋白抗体
英文名称： Anti-PARD6G/FITC
产品编号： HZ-13696R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PARD6G/FITC Conjugated antibody
FITC标记的PARD6G蛋白抗体
| 英文名称 | Anti-PARD6G/FITC |
| 中文名称 | FITC标记的PARD6G蛋白抗体 |
| 别 名 | PAR 6 gamma protein; par 6 partitioning defective 6 homolog gamma; PAR 6G; PAR6D; PAR6gamma; Partitioning defective 6 homolog gamma; PAR6G_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞分化 跨膜蛋白 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PARD6G |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PARD6G (partitioning defective 6 homolog gamma) is a 376 amino acid adaptor protein that is involved in cell polarization and asymmetrical cell division processes. PARD6G contains one OPR domain, one PDZ (DHR) domain and one pseudo-CRIB domain. The PDZ and pseudo-CRIB domains are required for interaction with Rho small GTPases. Through its complex formation with PARD3G, PARD6G participates in the linking of GTP-bound Rho small GTPases to atypical protein kinase C (PKC) proteins. This assembly is involved in formation of normal tight junctions at epithelial cell-cell contacts. When atypical PKC and PARD6G are expressed with a constitutively active RAC, the proteins colocalize to the membrane ruffles, which are structures that occur at the leading edge of polarized cells during movement. Though widely expressed, PARD6G is found at highest levels in adult and fetal kidney. Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Subunit: Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Subcellular Location: Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity). Tissue Specificity: Widely expressed, with a higher expression in fetal and adult kidney. Similarity: Belongs to the PAR6 family. Contains 1 OPR domain. Contains 1 PDZ (DHR) domain. Contains 1 pseudo-CRIB domain. Database links: Entrez Gene: 84552 Human Omim: 608976 Human SwissProt: Q9BYG4 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PARD6G(partitioning.ive 6 homologγ)是一种376个氨基酸适配子蛋白，参与细胞极化和不对称细胞分裂过程。PARD6G包含一个OPR域，一个PDZ（DHR）域和一个伪CRIB域。PDZ和伪CRIB域是必需的与Rho小GTP酶的相互作用。PARD6G通过与PARD3G形成复合物，参与GTP结合的Ro小GTP酶与不典型蛋白激酶C（PKC）蛋白的连接。该组件涉及在上皮细胞-细胞接触中形成正常紧密连接。当非典型PKC和PARD6G用组成活性RAC表达时，这些蛋白质在膜皱褶处集落，这些皱褶是在运动过程中发生在极化细胞的前缘的结构。虽然广泛表达，PARD6G发现在成人和胎儿肾脏的最高水平。