FITC标记的鸟氨酸脱羧酶抗体
产品名称: FITC标记的鸟氨酸脱羧酶抗体
英文名称: Anti-ODC/FITC
产品编号: HZ-
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-ODC/FITC Conjugated antibody
FITC标记的鸟氨酸脱羧酶抗体
英文名称 | Anti-ODC/FITC |
中文名称 | FITC标记的鸟氨酸脱羧酶抗体 |
别 名 | Ornithine decarboxylase 1; Ornithine decarboxylase; Dodc1; Odc 1; ODC; Odc1; ODC2; Ornithine decarboxylase 2; DCOR_HUMAN; Ornithine decarboxylase 1; Ornithine decarboxylase; Ornithine decarboxylase structural 1; RNODC. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 信号转导 新陈代谢 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 51kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human ODC |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Ornithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa. Subunit: Homodimer. Post-translational modifications: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues. Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. Database links: Entrez Gene: 281365 Cow Entrez Gene: 4953 Human Entrez Gene: 18263 Mouse Entrez Gene: 414408 Pig Entrez Gene: 24609 Rat Omim: 165640 Human SwissProt: P27117 Cow SwissProt: P11926 Human SwissProt: P00860 Mouse SwissProt: P09057 Rat Unigene: 7133 Cow Unigene: 467701 Human Unigene: 34102 Mouse Unigene: 874 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 鸟氨酸脱羧酶为多胺生物合成途径中的第一个限速酶 (催化合成多胺的第一步反应 ,即催化L -鸟氨酸脱羧生成腐胺 ) ,具有超常转变率和对于刺激的迅速反应性。 多胺广泛存在于生物体的各种细胞和组织中 ,是一种重要的代谢调控物质 ,它可直接与DNA相互作用 ,调节DNA构象 ,并参与RNA及蛋白质的合成 ,与细胞增殖、分化密切相关。经研究表明 ,哺乳动物细胞增殖体现出完全的多胺依赖性。ODC主要存在于胞浆中 |
鸟氨酸脱羧酶(ODC)是多胺生物合成途径中的起始酶和限速酶,参与鸟氨酸向腐胺的转化。几乎所有已知的促进细胞增殖的药物包括、药物、生长因子、有丝分裂原和肿瘤促进剂,ODC的生物活性都会被迅速诱导。据报道,在肺癌和结肠腺瘤和癌中,ODC mRNA水平升高。结直肠癌ODC活性明显高于腺瘤和正常粘膜。