CASP10 polyclonal antibody
产品名称： CASP10 polyclonal antibody
英文名称： CASP10 polyclonal antibody
产品编号： PAB9819
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CASP10.
- Immunogen:
- A synthetic peptide corresponding to amino acids 505-521 of human CASP10.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (0.5-1.0 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Caspases: the executioners of apoptosis.
Cohen GM.Biochem J. 1997 Aug 15;326 ( Pt 1):1-16.
- 2.
- Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling.
Vincenz C, Dixit VM.J Biol Chem. 1997 Mar 7;272(10):6578-83.
- 3.
- In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES.Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7464-9.
- Entrez GeneID:
- 843
- Gene Name:
- CASP10
- Gene Alias:
- ALPS2,FLICE2,MCH4
- Gene Description:
- caspase 10, apoptosis-related cysteine peptidase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- FADD-like ICE2,Fas-associated death domain protein,ICE-like apoptotic protease 4,apoptotic protease MCH-4,caspase 10,caspase 10, apoptosis-related cysteine protease,interleukin-1B-converting enzyme 2
- Interactome
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Asthma
- Asthma
- Breast cancer
- Breast Neoplasms
- Bronchial Hyperreactivity
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Clubfoot
- Colorectal Neoplasms
- Disease Progression
- Esophageal Neoplasms
- Gastrointestinal Stromal Tumors
- Genetic Predisposition to Disease
- Hematologic Diseases
- Leukemia
- Leukemia, chronic myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Lung Neoplasms