PPP3CC (C-term) Peptide
产品名称： PPP3CC (C-term) Peptide
英文名称： PPP3CC (C-term) Peptide
产品编号： P3309
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PPP3CC.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PPP3CC.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia.
Eastwood SL, Burnet PW, Harrison PJ.Biol Psychiatry. 2005 Apr 1;57(7):702-10.
- 2.
- Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit.
Gerber DJ, Hall D, Miyakawa T, Demars S, Gogos JA, Karayiorgou M, Tonegawa S.Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8993-8. Epub 2003 Jul 8.
- 3.
- Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E.Virology. 2002 Nov 10;303(1):174-80.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of PPP3CC polyclonal antibody (Cat # PAB4154) in A-375 cell lysate. PPP3CC (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PPP3CC polyclonal antibody (Cat # PAB4154) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 5533
- Protein Accession#:
- NP_005596;Q9BSS6
- Gene Name:
- PPP3CC
- Gene Alias:
- CALNA3
- Gene Description:
- protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
- Omim ID:
- 114107
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM
- Other Designations:
- calcineurin A gamma
- Gene Pathway